Total Synthesis of (-)-Strempeliopine.

ABSTRACT: A total synthesis of (-)-strempeliopine is disclosed that enlists a powerful SmI₂-mediated and BF₃·OEt₂-initiated dearomative transannular radical cyclization onto an indole by an N-acyl α-aminoalkyl radical that is derived by single electron reduction of an in situ generated iminium ion for formation of a quaternary center and the strategic C19-C2 bond in its core structure.

SUBMITTER: Zeng X 

PROVIDER: S-EPMC8405276 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature