Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector.

ABSTRACT: The risk of radiation damage has increased with the rapid development of nuclear technology and radiotherapy. Hence, research on radioprotective agents is of utmost importance. In the present study, a novel aminothiol compound 12, containing a linear alkylamino backbone and three terminal thiols, was synthesized. Owing to the appropriate capped groups in the chains, it has an improved permeability and oral bioavailability compared to other radioprotective agents. Oral administration of compound 12 improved the survival of mice that received lethal doses of γ-irradiation. Experimental results demonstrated that compound 12 not only mitigated total body irradiation-induced hematopoietic injury by increasing the frequencies of hematopoietic stem and progenitor cells but also prevented a

SUBMITTER: Li X 

PROVIDER: S-EPMC8405339 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature