Frailty predicts outcome of partial nephrectomy and guides treatment decision towards active surveillance and tumor ablation.

ABSTRACT:

Purpose

To examine frailty and comorbidity as predictors of outcome of nephron sparing surgery (NSS) and as decision tools for identifying candidates for active surveillance (AS) or tumor ablation (TA).

Methods

Frailty and comorbidity were assessed using the modified frailty index of the Canadian Study of Health and Aging (11-CSHA) and the age-adjusted Charlson-Comorbidity Index (aaCCI) as well as albumin and the radiological skeletal-muscle-index (SMI) in a cohort of n = 447 patients with localized renal masses. Renal tumor anatomy was classified according to the RENAL nephrometry system. Regression analyses were performed to assess predictors of surgical outcome of patients undergoing NSS as well as to identify possible influencing factors of patients undergoing alternativ

SUBMITTER: Walach MT 

PROVIDER: S-EPMC8405500 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature