PKM1 Exerts Critical Roles in Cardiac Remodeling Under Pressure Overload in the Heart.

ABSTRACT:

Background

Metabolic remodeling precedes most alterations during cardiac hypertrophic growth under hemodynamic stress. The elevation of glucose utilization has been recognized as a hallmark of metabolic remodeling. However, its role in cardiac hypertrophic growth and heart failure in response to pressure overload remains to be fully illustrated. Here, we aimed to dissect the role of cardiac PKM1 (pyruvate kinase muscle isozyme 1) in glucose metabolic regulation and cardiac response under pressure overload.

Methods

Cardiac-specific deletion of PKM1 was achieved by crossing the floxed PKM1 mouse model with the cardiomyocyte-specific Cre transgenic mouse. PKM1 transgenic mice were generated under the control of tetracycline response elements, and cardiac-specific overexpression

SUBMITTER: Li Q 

PROVIDER: S-EPMC8405569 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature