Enhancing influenza vaccine immunogenicity and efficacy through infection mimicry using silk microneedles.

ABSTRACT: Traditional bolus vaccine administration leads to rapid clearance of vaccine from lymphoid tissue. However, there is increasing evidence suggesting that the kinetics of antigen delivery can impact immune responses to vaccines, particularly when tailored to mimic natural infections. Here, we present the specific enhancements sustained release immunization confers to seasonal influenza vaccine, including the magnitude, durability, and breadth of humoral responses. To achieve sustained vaccine delivery kinetics, we have developed a microneedle array patch (MIMIX), with silk fibroin-formulated vaccine tips designed to embed in the dermis after a short application to the skin and release antigen over 1-2 weeks, mimicking the time course of a natural influenza infection. In a preclinical murine

SUBMITTER: Stinson JA 

PROVIDER: S-EPMC8405573 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature