Electrochemical Modulation of Carbon Monoxide-Mediated Cell Signaling.

ABSTRACT: Despite the critical role played by carbon monoxide (CO) in physiological and pathological signaling events, current approaches to deliver this messenger molecule are often accompanied by off-target effects and offer limited control over release kinetics. To address these challenges, we develop an electrochemical approach that affords on-demand release of CO through reduction of carbon dioxide (CO₂ ) dissolved in the extracellular space. Electrocatalytic generation of CO by cobalt phthalocyanine molecular catalysts modulates signaling pathways mediated by a CO receptor soluble guanylyl cyclase. Furthermore, by tuning the applied voltage during electrocatalysis, we explore the effect of the CO release kinetics on CO-dependent neuronal signaling. Finally, we integrate components o

SUBMITTER: Park J 

PROVIDER: S-EPMC8405587 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature