Connectivity of EEG synchronization networks increases for Parkinson's disease patients with freezing of gait.

ABSTRACT: Freezing of gait (FoG), a paroxysmal gait disturbance commonly experienced by patients with Parkinson's disease (PD), is characterized by sudden episodes of inability to generate effective forward stepping. Recent studies have shown an increase in beta frequency of local-field potentials in the basal-ganglia during FoG, however, comprehensive research on the synchronization between different brain locations and frequency bands in PD patients is scarce. Here, by developing tools based on network science and non-linear dynamics, we analyze synchronization networks of electroencephalography (EEG) brain waves of three PD patient groups with different FoG severity. We find higher EEG amplitude synchronization (stronger network links) between different brain locations as PD and FoG severity incr

SUBMITTER: Asher EE 

PROVIDER: S-EPMC8405655 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature