Adropin correlates with aging-related neuropathology in humans and improves cognitive function in aging mice.

ABSTRACT: The neural functions of adropin, a secreted peptide highly expressed in the brain, have not been investigated. In humans, adropin is highly expressed in astrocytes and peaks during critical postnatal periods of brain development. Gene enrichment analysis of transcripts correlating with adropin expression suggests processes relevant to aging-related neurodegenerative diseases that vary with age and dementia state, possibly indicating survivor bias. In people aged <40 y and 'old-old' (>75 y) diagnosed with dementia, adropin correlates positively with genes involved in mitochondrial processes. In the 'old-old' without dementia adropin expression correlates positively with morphogenesis and synapse function. Potent neurotrophic responses in primary cultured neurons are consistent with adropin

SUBMITTER: Banerjee S 

PROVIDER: S-EPMC8405681 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature