Mortality in South African Children and Adolescents Routinely Treated for Tuberculosis.

ABSTRACT:

Background

In South Africa, tuberculosis (TB) is a leading cause of death among those <20 years of age. We describe changes in TB mortality among children and adolescents in South Africa over a 13-year period, identify risk factors for mortality, and estimate excess TB-related mortality.

Methods

Retrospective analysis of all patients <20 years of age routinely recorded in the national electronic drug-susceptible TB treatment register (2004-2016). We developed a multivariable Cox regression model for predictors of mortality and used estimates of mortality among the general population to calculate standardized mortality ratios (SMRs).

Results

Between 2004 and 2016, 729 463 children and adolescents were recorded on TB treatment; 84.0% had treatment outcomes and 2.5% (18 

SUBMITTER: Osman M 

PROVIDER: S-EPMC8405866 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature