Quantitative ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography to assess pulmonary inflammation in COPD.

ABSTRACT:

Rationale

COPD and smoking are characterised by pulmonary inflammation. ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) imaging may improve knowledge of pulmonary inflammation in COPD patients and aid early development of novel therapies as an imaging biomarker.

Objectives

To evaluate pulmonary inflammation, assessed by FDG uptake, in whole and regional lung in "usual" (smoking-related) COPD patients, alpha-1 antitrypsin deficiency (α₁ATD) COPD patients, smokers without COPD and never-smokers using FDG PET/CT. Secondly, to explore cross-sectional associations between FDG PET/CT and systemic inflammatory markers in COPD patients and repeatability of the technique in COPD patients.

Methods

Data from two imaging

SUBMITTER: Vass L 

PROVIDER: S-EPMC8405867 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature