FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells.

ABSTRACT: At the initial stage of carcinogenesis, cell competition often occurs between newly emerging transformed cells and the neighboring normal cells, leading to the elimination of transformed cells from the epithelial layer. For instance, when RasV12-transformed cells are surrounded by normal cells, RasV12 cells are apically extruded from the epithelium. However, the underlying mechanisms of this tumor-suppressive process still remain enigmatic. We first show by electron microscopic analysis that characteristic finger-like membrane protrusions are projected from both normal and RasV12 cells at their interface. In addition, FBP17, a member of the F-BAR proteins, accumulates in RasV12 cells, as well as surrounding normal cells, which plays a positive role in the formation of finger-like protrusio

SUBMITTER: Kamasaki T 

PROVIDER: S-EPMC8405961 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature