Pesticides DEET, fipronil and maneb induce stress granule assembly and translation arrest in neuronal cells.

ABSTRACT: Pesticides entering our body, either directly or indirectly, are known to increase the risk of developing neurodegenerative disorders. The pesticide-induced animal models of Parkinson's disease and Alzheimer's disease recapitulates many of the pathologies seen in human patients and have become popular models for studying disease biology. However, the specific effect of pesticides at the cellular and molecular levels is yet to be fully established. Here we investigated the cellular effect of three commonly used pesticides: DEET, fipronil and maneb. Specifically, we looked at the effect of these pesticides in the formation of stress granules and the concomitant translational arrest in a neuronal cell line. Stress granules represent an ensemble of non-translating mRNAs and appear in cells und

SUBMITTER: Bhadauriya P 

PROVIDER: S-EPMC8405967 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature