International study on the outcome of locoregional therapy for liver transplant in hepatocellular carcinoma beyond Milan criteria.

ABSTRACT:

Background & aims

Good outcomes after liver transplantation (LT) have been reported after successfully downstaging to Milan criteria in more advanced hepatocellular carcinoma (HCC). We aimed to compare post-LT outcomes in patients receiving locoregional therapies (LRT) before LT according to Milan criteria and University of California San Francisco downstaging (UCSF-DS) protocol and 'all-comers'.

Methods

This multicentre cohort study included patients who received any LRT before LT from Europe and Latin America (2000-2018). We excluded patients with alpha-foetoprotein (AFP) above 1,000 ng/ml. Competing risk regression analysis for HCC recurrence was conducted, estimating subdistribution hazard ratios (SHRs) and corresponding 95% CIs.

Results

From 2,441 LT patients, 70

SUBMITTER: Degroote H 

PROVIDER: S-EPMC8405981 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature