Use of Nalmefene in Routine Practice: Results from a French Prospective Cohort Study and a National Database Analysis.

ABSTRACT:

Aims

Two complementary studies were used to assess the real-life use of nalmefene in alcohol-dependent patients and its impact on alcohol use health status.

Methods

USE-PACT was a prospective cohort study designed to evaluate the real-life effectiveness of nalmefene in the management of alcohol dependence, as assessed by total alcohol consumption (TAC) and number of heavy drinking days (HDD) at 1 year. USE-AM was a cohort study using data from the French nationwide claims database and was used to evaluate the external validity of the population in the prospective study.

Results

Overall, 256 of 700 new nalmefene users enrolled in the USE-PACT study had valid data at 1 year. After 1 year, patients treated with nalmefene showed a mean ± SD reduction from baseline in TAC

SUBMITTER: Aubin HJ 

PROVIDER: S-EPMC8406069 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature