Drosophila Antimicrobial Peptides and Lysozymes Regulate Gut Microbiota Composition and Abundance.

ABSTRACT: The gut microbiota affects the physiology and metabolism of animals and its alteration can lead to diseases such as gut dysplasia or metabolic disorders. Several reports have shown that the immune system plays an important role in shaping both bacterial community composition and abundance in Drosophila, and that immune deficit, especially during aging, negatively affects microbiota richness and diversity. However, there has been little study at the effector level to demonstrate how immune pathways regulate the microbiota. A key set of Drosophila immune effectors are the antimicrobial peptides (AMPs), which confer defense upon systemic infection. AMPs and lysozymes, a group of digestive enzymes with antimicrobial properties, are expressed in the gut and are good candidates for

SUBMITTER: Marra A 

PROVIDER: S-EPMC8406169 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature