Mucosal Bacteria Modulate Candida albicans Virulence in Oropharyngeal Candidiasis.

ABSTRACT: Oropharyngeal candidiasis (OPC) is the most prevalent oral infection in immunocompromised patients, primarily associated with Candida albicans. Increasing evidence points to a significant role of mucosal bacteria on the transition of C. albicans from commensal to pathogenic. In this work, we hypothesized that changes in the abundance or composition of the mucosal bacterial microbiota induced by dietary sucrose during the development of OPC can modulate C. albicans virulence. C. albicans burdens and mucosal lesions were evaluated in a mouse cortisone immunosuppression model amended with sucrose. We also analyzed the mucosal bacterial composition using 16S rRNA gene sequencing and culture methods. In immunocompetent mice, sucrose significantly increased total bacterial burdens and reduced al

SUBMITTER: Bertolini M 

PROVIDER: S-EPMC8406182 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature