Hidden Viral Sequences in Public Sequencing Data and Warning for Future Emerging Diseases.

ABSTRACT: RNA viruses cause numerous emerging diseases, mostly due to transmission from mammalian and avian reservoirs. Large-scale surveillance of RNA viral infections in these animals is a fundamental step for controlling viral infectious diseases. Metagenomic analysis is a powerful method for virus identification with low bias and has contributed substantially to the discovery of novel viruses. Deep-sequencing data have been collected from diverse animals and accumulated in public databases, which can be valuable resources for identifying unknown viral sequences. Here, we screened for infections of 33 RNA viral families in publicly available mammalian and avian sequencing data and found approximately 900 hidden viral infections. We also discovered six nearly complete viral genomes in livestock, w

SUBMITTER: Kawasaki J 

PROVIDER: S-EPMC8406186 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature