Lung Epithelial Signaling Mediates Early Vaccine-Induced CD4⁺ T Cell Activation and Mycobacterium tuberculosis Control.

ABSTRACT: Tuberculosis (TB) is one of the leading causes of death due to a single infectious agent. The development of a TB vaccine that induces durable and effective immunity to Mycobacterium tuberculosis (Mtb) infection is urgently needed. Early and superior Mtb control can be induced in M. bovis Bacillus Calmette-Guérin (BCG)-vaccinated hosts when the innate immune response is targeted to generate effective vaccine-induced immunity. In the present study, we show that innate activation of DCs is critical for mucosal localization of clonally activated vaccine-induced CD4⁺ T cells in the lung and superior early Mtb control. In addition, our study reveals that Th1/Th17 cytokine axis play an important role in superior vaccine-induced immunity. Our studies also show that

SUBMITTER: Das S 

PROVIDER: S-EPMC8406195 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature