Aspergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicity.

ABSTRACT: Aspergillus fumigatus is a major opportunistic fungal pathogen of immunocompromised and immunocompetent hosts. To successfully establish an infection, A. fumigatus needs to use host carbon sources, such as acetate, present in the body fluids and peripheral tissues. However, utilization of acetate as a carbon source by fungi in the context of infection has not been investigated. This work shows that acetate is metabolized via different pathways in A. fumigatus and that acetate utilization is under the regulatory control of a transcription factor (TF), FacB. A. fumigatus acetate utilization is subject to carbon catabolite repression (CCR), although this is only partially dependent on the TF and main regulator of CCR CreA. The available extracellular carbon source, in this case glucose and ac

SUBMITTER: Ries LNA 

PROVIDER: S-EPMC8406206 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature