Association of Short and Long Sleep Duration With Amyloid-β Burden and Cognition in Aging.

ABSTRACT:

Importance

Disrupted sleep is common in aging and is associated with cognition. Age-related changes to sleep are associated with multiple causes, including early Alzheimer disease pathology (amyloid β [Aβ]), depression, and cardiovascular disease.

Objective

To investigate the associations between self-reported sleep duration and brain Aβ burden as well as the demographic, cognitive, and lifestyle variables in adults with normal cognition.

Design, setting, and participants

This cross-sectional study obtained data from participants in the Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) study, which is being conducted in 67 sites in the United States, Canada, Australia, and Japan. The sample for this analysis consisted of individuals aged 65 to 85 years w

SUBMITTER: Winer JR 

PROVIDER: S-EPMC8406215 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature