Genomic Diversity of Azole-Resistant Aspergillus fumigatus in the United States.

ABSTRACT: Azole resistance in pathogenic Aspergillus fumigatus has become a global public health issue threatening the use of medical azoles. The environmentally occurring resistance mutations, TR₃₄/L98H (TR₃₄) and TR₄₆/Y121F/T289A (TR₄₆), are widespread across multiple continents and emerging in the United States. We used whole-genome single nucleotide polymorphism (SNP) analysis on 179 nationally represented clinical and environmental A. fumigatus genomes from the United States along with 18 non-U.S. genomes to evaluate the genetic diversity and foundation of the emergence of azole resistance in the United States. We demonstrated the presence of clades of A. fumigatus isolates: clade A (17%) comprised a global collection of clinical and environmental azo

SUBMITTER: Etienne KA 

PROVIDER: S-EPMC8406307 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature