CdrS Is a Global Transcriptional Regulator Influencing Cell Division in Haloferax volcanii.

ABSTRACT: Transcriptional regulators that integrate cellular and environmental signals to control cell division are well known in bacteria and eukaryotes, but their existence is poorly understood in archaea. We identified a conserved gene (cdrS) that encodes a small protein and is highly transcribed in the model archaeon Haloferax volcanii. The cdrS gene could not be deleted, but CRISPR interference (CRISPRi)-mediated repression of the cdrS gene caused slow growth and cell division defects and changed the expression of multiple genes and their products associated with cell division, protein degradation, and metabolism. Consistent with this complex regulatory network, overexpression of cdrS inhibited cell division, whereas overexpression of the operon encoding both CdrS an

SUBMITTER: Liao Y 

PROVIDER: S-EPMC8406309 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature