Case report: Rare myeloid sarcoma development following renal transplantation with KRAS and DNMT3A gene mutations.

ABSTRACT:

Background

A high incidence of malignant tumors, such as post-transplant lymphoproliferative disorders (PTLD), Kaposi sarcoma, and renal cancer is common in solid organ and bone marrow transplant recipients. However, myeloid sarcoma (MS) after renal transplantation has rarely been reported and the diagnosis is challenging due to its low incidence.

Case presentation

Here, we report a rare case of a 49-year-old man who developed myeloid sarcoma (MS) in the transplanted kidney two years after renal transplantation. Next-generation sequencing (NGS) showed mutations of KRAS and DNMT3A genes in the MS, and no gene mutations in the bone marrow. He presented a normal karyotype of 46, XY. Following treatment with 6 cycles of systemic chemotherapy, the patient was in satisfactory cond

SUBMITTER: Wu D 

PROVIDER: S-EPMC8406562 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature