Long-term personal air pollution exposure and risk for acute exacerbation of idiopathic pulmonary fibrosis.

ABSTRACT:

Background

Urban air pollution is involved in the progress of idiopathic pulmonary fibrosis (IPF). Its potential role on the devastating event of Acute Exacerbation of IPF (AE-IPF) needs to be clarified. This study examined the association between long-term personal air pollution exposure and AE- IPF risk taking into consideration inflammatory mediators and telomere length (TL).

Methods

All consecutive IPF-patients referred to our Hospital from October 2013-June 2019 were included. AE-IPF events were recorded and inflammatory mediators and TL measured. Long-term personal air pollution exposures were assigned to each patient retrospectively, for O₃, NO₂, PM_2.5 [and PM₁₀, based on geo-coded residential addresses. Logistic regression

SUBMITTER: Tomos I 

PROVIDER: S-EPMC8406600 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature