Investigator initiated trials versus industry sponsored trials - translation of randomized controlled trials into clinical practice (IMPACT).

ABSTRACT:

Background

Healthcare decisions are ideally based on clinical trial results, published in study registries, as journal articles or summarized in secondary research articles. In this research project, we investigated the impact of academically and commercially sponsored clinical trials on medical practice by measuring the proportion of trials published and cited by systematic reviews and clinical guidelines.

Methods

We examined 691 multicenter, randomized controlled trials that started in 2005 or later and were completed by the end of 2016. To determine whether sponsorship/funding and place of conduct influence a trial's impact, we created four sub-cohorts of investigator initiated trials (IITs) and industry sponsored trials (ISTs): 120 IITs and 171 ISTs with German contribut

SUBMITTER: Blumle A 

PROVIDER: S-EPMC8406615 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature