Multi-Omics Analysis of the Expression and Prognosis for FKBP Gene Family in Renal Cancer.

ABSTRACT:

Background

The FK506-binding protein (FKBP) is a family of intracellular receptors that can bind specifically to the immunosuppressant FK506 and rapamycin. Although FKBPs play crucial roles in biological processes and carcinogenesis, their prognostic value and molecular mechanism in clear cell renal cell carcinoma (ccRCC) remain unclear.

Methods

Using pan-cancer data from The Cancer Genome Atlas (TCGA) and public databases, we analyzed the expression and correlation of FKBPs in 33 tumor types. Survival and Cox regression analyses were employed to explore the prognostic value of FKBPs. The relationship with tumor microenvironment and stemness indices was taken into account to evaluate the function of FKBPs. We constructed a risk score model to predict the prognosis of patient

SUBMITTER: Sun Z 

PROVIDER: S-EPMC8406630 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature