Duo: A Signature Based Method to Batch-Analyze Functional Similarities of Proteins.

ABSTRACT: With the rapid advancement of sequencing technology, handling of large sequencing data to analyze for protein coding capacity and functionality of predicted proteins has become an urgent demand. There is a lack of simple and effective tools to functionally annotate large number of unknown proteins in a personalized and customized workflow. To address this, we developed Duo, which batch-analyze functional similarities of predicted proteins. Duo can screen query proteins with specific characteristics based on highly flexible and customizable reference inputs from the user. In the current study, Duo was applied to screen for virulence associated proteins in the genome-sequence of Salmonella Typhimurium. Based on the analysis, recommendation for choice of Seed_database in order to get a

SUBMITTER: Fei X 

PROVIDER: S-EPMC8406696 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature