Nociceptor Overexpression of Na_V1.7 Contributes to Chronic Muscle Pain Induced by Early-Life Stress.

ABSTRACT: Adult rats previously submitted to neonatal limited bedding (NLB), a model of early-life stress, display muscle mechanical hyperalgesia and nociceptor hyperexcitability, the underlying mechanism for which is unknown. Since voltage-gated sodium channel subtype 7 (Na_V1.7) contributes to mechanical hyperalgesia in several preclinical pain models and is critical for nociceptor excitability, we explored its role in the muscle hyperalgesia exhibited by adult NLB rats. Western blot analyses demonstrated increased Na_V1.7 protein expression in L4-L5 dorsal root ganglia (DRG) from adult NLB rats, and antisense oligodeoxynucleotide (AS ODN) targeting Na_V1.7 alpha subunit mRNA attenuated the expression of Na_V1.7 in DRG extracts. While this AS ODN did not aff

SUBMITTER: Alvarez P 

PROVIDER: S-EPMC8406703 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature