Identification of unique ROH regions with unfavorable effects on production and fertility traits in Canadian Holsteins.

ABSTRACT:

Background

The advent of genomic information and the reduction in the cost of genotyping have led to the use of genomic information to estimate genomic inbreeding as an alternative to pedigree inbreeding. Using genomic measures, effects of genomic inbreeding on production and fertility traits have been observed. However, there have been limited studies on the specific genomic regions causing the observed negative association with the trait of interest. Our aim was to identify unique run of homozygosity (ROH) genotypes present within a given genomic window that display negative associations with production and fertility traits and to quantify the effects of these identified ROH genotypes.

Methods

In total, 50,575 genotypes based on a 50K single nucleotide polymorphism (SNP) a

SUBMITTER: Makanjuola BO 

PROVIDER: S-EPMC8406729 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature