Associations of CKD risk factors and longitudinal changes in urine biomarkers of kidney tubules among women living with HIV.

ABSTRACT:

Background

Novel urine biomarkers have enabled the characterization of kidney tubular dysfunction and injury among persons living with HIV, a population at an increased risk of kidney disease. Even though several urine biomarkers predict progressive kidney function decline, antiretroviral toxicity, and mortality in the setting of HIV infection, the relationships among the risk factors for chronic kidney disease (CKD) and urine biomarkers are unclear.

Methods

We assessed traditional and infection-related CKD risk factors and measured 14 urine biomarkers at baseline and at follow-up among women living with HIV in the Women's Interagency Health Study (WIHS). We then used simultaneously adjusted multivariable linear regression models to evaluate the associations of CKD risk fact

SUBMITTER: Muiru AN 

PROVIDER: S-EPMC8406753 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature