Aβ misfolding in blood plasma is inversely associated with body mass index even in middle adulthood.

ABSTRACT:

Background

To understand the potential for early intervention and prevention measures in Alzheimer's disease, the association between risk factors and early pathological change needs to be assessed. Hence, the aim of this study was to determine whether risk factors of Alzheimer's clinical syndrome (clinical AD), such as body mass index (BMI), are associated with Aβ misfolding in blood, a strong risk marker for AD among older adults.

Methods

Information on risk factors and blood samples were collected at baseline in the ESTHER study, a population-based cohort study of older adults (age 50-75 years) in Germany. Aβ misfolding in blood plasma was analyzed using an immuno-infrared-sensor in a total of 872 participants in a nested case-control design among incident dementia cases

SUBMITTER: Mollers T 

PROVIDER: S-EPMC8406782 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature