Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice.

ABSTRACT: Although hepatocellular cancer (HCC) usually occurs in the setting of liver fibrosis, the causal relationship between liver fibrosis and HCC is unclear. in vivo and in vitro models of HCC involving Col^r/r mice (that produce a collagenase-resistant type I collagen) or wild-type (WT) mice were used to assess the relationship between type I collagen, liver fibrosis, and experimental HCC. HCC was either chemically induced in WT and Col^r/r mice or Hepa 1-6 cells were engrafted into WT and Col^r/r livers. The effect of hepatic stellate cells (HSCs) from WT and Col^r/r mice on the growth of Hepa 1-6 cells was studied by using multicellular tumor spheroids and xenografts. Collagen type I deposition and fibrosis were increased in Col^r/r mice, but

SUBMITTER: Baglieri J 

PROVIDER: S-EPMC8406794 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature