Plasticity of the Immune System in Children Following Treatment Interruption in HIV-1 Infection.

ABSTRACT: It is intriguing that, unlike adults with HIV-1, children with HIV-1 reach a greater CD4⁺ T cell recovery following planned treatment cessation. The reasons for the better outcomes in children remain unknown but may be related to increased thymic output and diversity of T cell receptor repertoires. HIV-1 infected children from the PENTA 11 trial tolerated planned treatment interruption without adverse long-term clinical, virological, or immunological consequences, once antiretroviral therapy was re-introduced. This contrasts to treatment interruption trials of HIV-1 infected adults, who had rapid changes in T cells and slow recovery when antiretroviral therapy was restarted. How children can develop such effective immune responses to planned treatment interruption may be critica

SUBMITTER: Sandgaard KS 

PROVIDER: S-EPMC8406805 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature