Altered synthesis of genes associated with short-chain fatty acids in the gut of patients with atrial fibrillation.

ABSTRACT:

Background

The gut microbiota provides health benefits in humans by producing short-chain fatty acids (SCFAs), whose deficiency causes multiple disorders and inflammatory diseases. However, gut bacteria producing SCFAs in patients with atrial fibrillation (AF), an arrhythmia with increasing prevalence, have not been reported. To investigate major gut microbial organisms related to SCFA synthesis, SCFAs-associated KEGG orthologues (KOs), enzymatic genes, and potential producers were examined according to metagenomic data-mining in a northern Chinese cohort comprising 50 non-AF control and 50 AF patients.

Results

Compared with non-AF controls, individuals with AF had marked differences in microbial genes involved in SCFA-related synthesis, including 125 KOs and 5 SCFAs-related

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8406843 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature