Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment.

ABSTRACT:

Background

The combinatorial effect of multiple genetic factors calculated as a polygenic risk score (PRS) has been studied to predict disease progression to Alzheimer's disease (AD) from mild cognitive impairment (MCI). Previous studies have investigated the performance of PRS in the prediction of disease progression to AD by including and excluding single nucleotide polymorphisms within the region surrounding the APOE gene. These studies may have missed the APOE genotype-specific predictability of PRS for disease progression to AD.

Methods

We analyzed 732 MCI from the Alzheimer's Disease Neuroimaging Initiative cohort, including those who progressed to AD within 5 years post-baseline (n = 270) and remained stable as MCI (n = 462). The predictability of PRS including and ex

SUBMITTER: Pyun JM 

PROVIDER: S-EPMC8406896 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature