Distribution and diversity of dimetal-carboxylate halogenases in cyanobacteria.

ABSTRACT:

Background

Halogenation is a recurring feature in natural products, especially those from marine organisms. The selectivity with which halogenating enzymes act on their substrates renders halogenases interesting targets for biocatalyst development. Recently, CylC - the first predicted dimetal-carboxylate halogenase to be characterized - was shown to regio- and stereoselectively install a chlorine atom onto an unactivated carbon center during cylindrocyclophane biosynthesis. Homologs of CylC are also found in other characterized cyanobacterial secondary metabolite biosynthetic gene clusters. Due to its novelty in biological catalysis, selectivity and ability to perform C-H activation, this halogenase class is of considerable fundamental and applied interest. The study of CylC-like e

SUBMITTER: Eusebio N 

PROVIDER: S-EPMC8406957 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature