Effect of a single dose of oral azithromycin on malaria parasitaemia in children: a randomized controlled trial.

ABSTRACT:

Background

Azithromycin has recently been shown to reduce all-cause childhood mortality in sub-Saharan Africa. One potential mechanism of this effect is via the anti-malarial effect of azithromycin, which may help treat or prevent malaria infection. This study evaluated short- and longer-term effects of azithromycin on malaria outcomes in children.

Methods

Children aged 8 days to 59 months were randomized in a 1:1 fashion to a single oral dose of azithromycin (20 mg/kg) or matching placebo. Children were evaluated for malaria via thin and thick smear and rapid diagnostic test (for those with tympanic temperature ≥ 37.5 °C) at baseline and 14 days and 6 months after treatment. Malaria outcomes in children receiving azithromycin versus placebo were compared at each follow-up t

SUBMITTER: Coulibaly B 

PROVIDER: S-EPMC8407066 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature