Halogenases: a palette of emerging opportunities for synthetic biology-synthetic chemistry and C-H functionalisation.

ABSTRACT: The enzymatic generation of carbon-halogen bonds is a powerful strategy used by both nature and synthetic chemists to tune the bioactivity, bioavailability and reactivity of compounds, opening up the opportunity for selective C-H functionalisation. Genes encoding halogenase enzymes have recently been shown to transcend all kingdoms of life. These enzymes install halogen atoms into aromatic and less activated aliphatic substrates, achieving selectivities that are often challenging to accomplish using synthetic methodologies. Significant advances in both halogenase discovery and engineering have provided a toolbox of enzymes, enabling the ready use of these catalysts in biotransformations, synthetic biology, and in combination with chemical catalysis to enable late stage C-H functionalisatio

SUBMITTER: Crowe C 

PROVIDER: S-EPMC8407142 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature