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Chimeric antigen receptor-T cells immunotherapy for targeting breast cancer.

ABSTRACT: Redirected chimeric antigen receptor (CAR) T-cells can recognize and eradicate cancer cells in a major histocompatibility complex independent manner. Genetic engineering of T cells through CAR expression has yielded great results in the treatment of hematological malignancies compared with solid tumors. There has been a constant effort to enhance the effectiveness of these living drugs, due to their limited success in targeting solid tumors. Poor T cell trafficking, tumor-specific antigen selection, and the immunosuppressive tumor microenvironment are considered as the main barriers in targeting solid tumors by CAR T-cells. Here, we reviewed the current state of CAR T-cell therapy in breast cancer, as the second cancer-related death in women worldwide, as well as some strategies adopted to keep the main limitations of CAR T-cells under control. Also, we summarized various approaches that have been developed to enhance the therapeutic outcomes of this treatment in solid tumors targeting.

SUBMITTER: Rahimmanesh I

PROVIDER: S-EPMC8407156 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Chimeric antigen receptor-T cells immunotherapy for targeting breast cancer.

Rahimmanesh Ilnaz I Khanahmad Hossein H

Research in pharmaceutical sciences 20210819 5

Redirected chimeric antigen receptor (CAR) T-cells can recognize and eradicate cancer cells in a major histocompatibility complex independent manner. Genetic engineering of T cells through CAR expression has yielded great results in the treatment of hematological malignancies compared with solid tumors. There has been a constant effort to enhance the effectiveness of these living drugs, due to their limited success in targeting solid tumors. Poor T cell trafficking, tumor-specific antigen select ...[more]

PMID: 34522192

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