Accessory Genomic Epidemiology of Cocirculating Acinetobacter baumannii Clones.

ABSTRACT: Acinetobacter baumannii has become one of the most important multidrug-resistant nosocomial pathogens all over the world. Nonetheless, very little is known about the diversity of A. baumannii lineages coexisting in hospital settings. Here, using whole-genome sequencing, epidemiological data, and antimicrobial susceptibility tests, we uncover the transmission dynamics of extensive and multidrug-resistant A. baumannii in a tertiary hospital over a decade. Our core genome phylogeny of almost 300 genomes suggests that there were several introductions of lineages from international clone 2 into the hospital. The molecular dating analysis shows that these introductions happened in 2006, 2007, and 2013. Furthermore, using the accessory genome, we show that these lineages were extensively dissemin

SUBMITTER: Mateo-Estrada V 

PROVIDER: S-EPMC8407383 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature