PsaF Is a Membrane-Localized pH Sensor That Regulates psaA Expression in Yersinia pestis.

ABSTRACT: The Yersinia pestis pH 6 antigen (PsaA) forms fimbria-like structures and is required for full virulence during bubonic plague. High temperature and low pH regulate PsaA production, and while recent work has uncovered the molecular aspects of temperature control, the mechanisms underlying this unusual regulation by pH are poorly understood. Using defined growth conditions, we recently showed that high levels of PsaE and PsaF (two regulatory proteins required for expression of psaA) are present at mildly acidic pH, but these levels are greatly reduced at neutral pH, resulting in low psaA expression. In prior work, the use of translational reporters suggested that pH had no impact on translation of psaE and psaF, but rather affected protein stability of PsaE and/o

SUBMITTER: Quinn JD 

PROVIDER: S-EPMC8407435 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature