Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2 : A Prospective Cohort Study.

ABSTRACT:

Background

Patients with chronic inflammatory disease (CID) treated with immunosuppressive medications have increased risk for severe COVID-19. Although mRNA-based SARS-CoV-2 vaccination provides protection in immunocompetent persons, immunogenicity in immunosuppressed patients with CID is unclear.

Objective

To determine the immunogenicity of mRNA-based SARS-CoV-2 vaccines in patients with CID.

Design

Prospective observational cohort study.

Setting

Two U.S. CID referral centers.

Participants

Volunteer sample of adults with confirmed CID eligible for early COVID-19 vaccination, including hospital employees of any age and patients older than 65 years. Immunocompetent participants were recruited separately from hospital employees. All participants received

SUBMITTER: Deepak P 

PROVIDER: S-EPMC8407518 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature