Ontology highlight
ABSTRACT:
SUBMITTER: Cazzola M
PROVIDER: S-EPMC8407524 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Cazzola Mario M Ora Josuel J Cavalli Francesco F Rogliani Paola P Matera Maria Gabriella MG
Biologics : targets & therapy 20210827
Several mAbs have been tested or are currently under clinical evaluation for the treatment of COPD. They can be subdivided into those that aim to block specific pro-inflammatory and pro-neutrophilic cytokines and chemokines, such as TNF-α, IL-1β, CXCL8 and IL-1β, and those that act on T2-mediated inflammation, respectively, by blocking IL-5 and/or its receptor, preventing IL-4 and IL-13 signaling, affecting IL-33 pathway and blocking TSLP. None of these approaches has proved to be effective, pro ...[more]