Limited versus Extended Pelvic Lymph Node Dissection for Prostate Cancer: A Randomized Clinical Trial.

ABSTRACT:

Background

Pelvic lymph node dissection (PLND) is the most reliable procedure for lymph node staging. However, the therapeutic benefit remains unproven; although most radical prostatectomies at academic centers are accompanied by PLND, there is no consensus regarding the optimal anatomical extent of PLND.

Objective

To evaluate whether extended PLND results in a lower biochemical recurrence rate.

Design, setting, and participants

We conducted a single-center randomized trial. Patients, enrolled between October 2011 and March 2017, were scheduled to undergo radical prostatectomy and PLND. Patients were assigned to limited or extended PLND by cluster randomization. Specifically, surgeons were randomized to perform limited or extended PLND for 3-mo periods.

Interventio

SUBMITTER: Touijer KA 

PROVIDER: S-EPMC8407534 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature