Higher entropy observed in SARS-CoV-2 genomes from the first COVID-19 wave in Pakistan.

ABSTRACT:

Background

We investigated the genome diversity of SARS-CoV-2 associated with the early COVID-19 period to investigate evolution of the virus in Pakistan.

Materials and methods

We studied ninety SARS-CoV-2 strains isolated between March and October 2020. Whole genome sequences from our laboratory and available genomes were used to investigate phylogeny, genetic variantion and mutation rates of SARS-CoV-2 strains in Pakistan. Site specific entropy analysis compared mutation rates between strains isolated before and after June 2020.

Results

In March, strains belonging to L, S, V and GH clades were observed but by October, only L and GH strains were present. The highest diversity of clades was present in Sindh and Islamabad Capital Territory and the least in Punjab provi

SUBMITTER: Ghanchi NK 

PROVIDER: S-EPMC8407562 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature