Relating simulation studies by provenance-Developing a family of Wnt signaling models.

ABSTRACT: For many biological systems, a variety of simulation models exist. A new simulation model is rarely developed from scratch, but rather revises and extends an existing one. A key challenge, however, is to decide which model might be an appropriate starting point for a particular problem and why. To answer this question, we need to identify entities and activities that contributed to the development of a simulation model. Therefore, we exploit the provenance data model, PROV-DM, of the World Wide Web Consortium and, building on previous work, continue developing a PROV ontology for simulation studies. Based on a case study of 19 Wnt/β-catenin signaling models, we identify crucial entities and activities as well as useful metadata to both capture the provenance information from individual sim

SUBMITTER: Budde K 

PROVIDER: S-EPMC8407594 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature