Paternal body mass index and offspring DNA methylation: findings from the PACE consortium.

ABSTRACT:

Background

Accumulating evidence links paternal adiposity in the periconceptional period to offspring health outcomes. DNA methylation has been proposed as a mediating mechanism, but very few studies have explored this possibility in humans.

Methods

In the Pregnancy And Childhood Epigenetics (PACE) consortium, we conducted a meta-analysis of coordinated epigenome-wide association studies (EWAS) of paternal prenatal body mass index (BMI) (with and without adjustment for maternal BMI) in relation to DNA methylation in offspring blood at birth (13 data sets; total n = 4894) and in childhood (6 data sets; total n = 1982).

Results

We found little evidence of an association at either time point: at all CpGs, the false-discovery-rate-adjusted P-values were >0.05. In secondar

SUBMITTER: Sharp GC 

PROVIDER: S-EPMC8407864 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature