Genetic risk scores for cardiometabolic traits in sub-Saharan African populations.

ABSTRACT:

Background

There is growing support for the use of genetic risk scores (GRS) in routine clinical settings. Due to the limited diversity of current genomic discovery samples, there are concerns that the predictive power of GRS will be limited in non-European ancestry populations. GRS for cardiometabolic traits were evaluated in sub-Saharan Africans in comparison with African Americans and European Americans.

Methods

We evaluated the predictive utility of GRS for 12 cardiometabolic traits in sub-Saharan Africans (AF; n = 5200), African Americans (AA; n = 9139) and European Americans (EUR; n = 9594). GRS were constructed as weighted sums of the number of risk alleles. Predictive utility was assessed using the additional phenotypic variance explained and the increase in discrimi

SUBMITTER: Ekoru K 

PROVIDER: S-EPMC8407873 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature