The miR-193a-5p/NCX2/AKT axis promotes invasion and metastasis of osteosarcoma.

ABSTRACT: MiR-193a-5p has been observed to have oncogenic or tumor suppressive functions in different kinds of cancers, but its role and molecular mechanism in osteosarcoma are elusive. Na⁺/Ca²⁺ exchangers (NCX1, NCX2 and NCX3) normally extrude Ca²⁺ from the cell, and deregulation of the intracellular Ca²⁺ homeostasis is related to several kinds of diseases, including cancer. The present study demonstrated that miR-193a-5p was upregulated in osteosarcoma tissues compared with the corresponding adjacent noncancerous tissues, and promoted colony formation, migration, invasion and epithelial-mesenchymal transition (EMT) in osteosarcoma cells (SaOS-2 and U-2OS), as well as metastasis in a murine xenograft model. Tandem mass tag-based quantitative proteomics an

SUBMITTER: Chen R 

PROVIDER: S-EPMC8408106 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature