Optimal human pathogenic T_H2 cell effector function requires local epithelial cytokine signaling.

ABSTRACT:

Background

IL-33 is an emerging key factor in development of allergic diseases. The IL-33 receptor (suppressor of tumorigenicity [ST2]) is a differentially expressed gene in pathogenic T_H2 cells, but its role in T-cell effector function has not been elucidated.

Objective

We investigated the role of IL-33 in modulating circulating allergen-specific T-cell responses. We hypothesized that selective ST2 expression on allergen-specific CD4⁺ T cells would confer susceptibility to the effects of IL-33.

Methods

PBMCs from subjects with food allergy, inhalant allergy, and no allergy were obtained on the basis of clinical history and serum IgE level. A T-cell receptor-dependent CD154 upregulation assay and direct peptide major histocompatibility complex cl

SUBMITTER: Calise J 

PROVIDER: S-EPMC8408285 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature